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Effect of Konjac Glucomannan on Hyperuricemic Rats

Yuan Zhang, Xin Wu, Tiangang Shuai, Chunmei Wu, Jiujun Shen, Geng Zhong

Objective: The effect of konjac glucomannan (KGM) on hyperuricemic rats was studied.

Method: To establish a hyperuricemic model, rats in experiment groups were orally administrated with adenine and potassium oxonate every morning and continuously fed diets containing 20% yeast. Rats in positive drug group and KGM groups were orally administrated with benzbromarone and KGM respectively every afternoon. Blood was collected weekly and rats were sacrificed at 4th week, the biochemical indexes and histological analysis were measured.

Results: During the experiment, the level of uric acid (UA), Creatinine (Cr) and blood urea nitrogen (BUN)in model group increased significantly, indicating a hyperuricemic model was established successfully. But the level of the three indexes in positive drug group and KGM groups were lower to different degrees. UA in middle group exhibited the lowest level and had no significant with that of control group in the end. Besides, the activities of serum xanthine oxidase (XOD) and serum adenosine deaminase (ADA) in model group gradually increased and had significant difference with that of control group. KGM could significantly decrease the activities of XOD and ADA in serum and in liver, especially at middle dose. However, the activity of guanine deaminase (GD) did not have a significant fluctuation either in serum or liver during the experiment. Pathological analysis of kidneys showed KGM caused a strong reduction in the number of urate crystal, rats in high dose group had the lightest renal histological lesion.