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Erythrocyte Membrane Stabilization Method: An Empirical Evaluation of Anti-Inflammatory Activity of Methanol Extract of Syzygium cumini (Pulp)

Tanwy Chowdhury, Md. Abdul Motaleb Bhuiya, Sumaiya Nahid, Antica Barua

The motive of this experiment was to evaluate the anti-inflammatory activity of methanol extract of Syzygium cumini pulp or fruit. Fresh fruits of Syzygium cumini were collected, dried, powdered and extracted with methanol. In search of phytochemical constituents accountable for anti-inflammatory activity, primary phytochemical screening of crude methanol extracts of the pulp was done by using placed methods. The extract was then subjected to membrane stabilization method. Results brought out the presence of phytochemicals like alkaloid, flavonoid, anthocyanin, tannins, steroids, and saponin. In membrane stabilizing assay, crude methanol extract of pulp of Syzygium cumini was found to be very effective for stabilizing erythrocyte membrane in hypotonic solution. The highest concentration of the pulp extract (1000 µg/ml) showed 62.381% inhibition with methanol extract compared with the standard drug Diclofenac sodium, which accounted for 87.143% of inhibition. The result of the present study demonstrates a favorable baseline in progression for the possible use of pulp or fruit of Syzygium cumini to treat inflammation.