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Chemical analysis and in vitro evaluation of antiurolithiatic activity of Aerva lanata (Linn.) Juss. Ex Schult. roots

KN Sunil Kumar*, Suchitra Narayan Prabhu, B Ravishankar, Sahana, B Yashovarma

Background: Aerva lanata (Linn.) Juss. ex Schult. - Amaranthaceae is an herbaceous weed found throughout tropical India. The plant is known as pashanabheda/ gorakshaganja in Ayurvedic system of medicine. The roots are diuretic and used as cure for urinary troubles including stones. In the present manuscript, experimental evidences regarding antiurolithiatic activity of roots of A. lanata are reported in support of its use in lithiasis.

Objective: In the current study it attempted to evaluate the effectiveness of roots of Aerva lanata on renal calculus formation In vitro.

Methods: Investigation of antiurolithic activity was carried out by simultaneous flow static model (S.S.M). Dissolution of precipitate of calcium oxalate and calcium phosphate was determined by (S.S.M).

Results: One per cent aqueous extract preparation of A. lanata root was good at controlling calcium phosphate crystallization. Five per cent aqueous extract was good on calcium oxalate crystallization though it controls both type of crystal formation.

Conclusions: This attempt would provide encouragement for further research on novel drug development for prevention and treatment of urolithiasis.