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Supramolecular Chemistry: An Alternative Approach to Improve Potential Active Pharmaceutical Ingredient��?s (APIs)

Renu Chadha and Dimpy Rani

Supramolecular interactions in the solid state of a crystalline from plays a vital role in controlling of its physicochemical properties. The tailoring of these non-covalent interactions, in already established APIs can be utilized to design a new chemical entity with improved biopharmaceutical properties. This review article throws the light on the supramolecular chemistry in different crystalline forms (polymorphs, cyclodextrin complexes, salts and co-crystals) and how the supramolecular architecture has contributed for the betterment of the potential APIs.