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Preparation and In-Vitro Evaluation of Mirtazapine Oral Films

Anjali Nippani, Vijendar C, Anil Dindigala, Anil Goud Kandhula, Chandra shekar K and Anil Alabadri

Mirtazapine is an antidepressant drug, which affects chemical pathway in the brain that is unbalanced in people with depression. In Mirtazapine oral films HPMC (Hydroxy propyl methyl cellulose) is used as a polymer. The films are prepared by solvent casting method. The prepared batches of films were evaluated for durability, proportion elongation, folding endurance and dissolution. Formulation F3 was found to be promising and it was tested for In-vitro drug release pattern which showed 100% drug release 8mins. The formulation F3 has shown better control over drug release compared to marketed product.