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Post-Marketing In-vitro Comparative Studies of Different Brands of Paracetamol Tablets Available in Misurata Market, Libya

Omar Rwaiha,

Post marketing in-vitro studying of products is an important to investigate quality of medicines at various intervals time during their shelf life. Paracetamol is a widely used analgesic and antipyretic drug worldwide. The selected five brands of Paracetamol tablets in Misurata market, Libya, were tested for various parameters of quality control tests. 120 tablets for each brand were required to achieve: Uniformity of drug content, weight variation, hardness, friability, disintegration time and dissolution. All brands showed acceptable friability values less than 1% except Aspar® Paracetamol tablets were represent extremely high value around twenty times more than standard level. Uniformity of drug content for all brands claimed that BP standards were values are matches the percentage of loaded drug in the tablets for all brands (around 100% ± 5). Moreover, the release rate of different brands of Paracetamol was satisfactory within 45 minutes