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Mortality Risk Factor Stratification in a Retrospective Cohort of Hospitalized Patients with Community Acquired Pneumonia

Meredith Sloan1*, Anna Owings1, Sarah Glover1, Julia Liu2, George E Abraham1, Brian Claggett3, Michal Senitko1

A retrospective cohort was used to investigate the conditions that affected mortality in hospitalized Community-Acquired Pneumonia (CAP) patients. 1223 patients were identified based on diagnostic codes. T-tests, chisquared tests, and logistic regression models were used to evaluate the data. There were 613 (50%) patients on proton pump inhibitors (PPIs) with a mortality rate of 26.3% vs. 13.4% in non-PPI users (P<0.001). Variables that increased the risk of death included: each decade of age, odds ratio (OR)=1.15 (95% confidence interval 1.07 to 1.23), congestive heart failure OR=2.06 (1.46 to 2.91), cancer OR=1.66 (1.20 to 2.23), cardiovascular disease OR=2.04 (1.19 to 3.49), and stroke OR=1.53 (1.05 to 2.23). Statin use was associated with improved mortality, OR=0.28 (0.13 to 0.59). Statin use may improve and PPIs may worsen mortality in CAP.