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Mechanical and Thermal Kinetic Parameters of Metformin Hydrochloride Crystals.

Ramukutty S, Jeyasudha R and Ramachandran E

Metformin hydrochloride single crystals of large size: 15.5 × 1 × 1.5 mm3 were grown in aqueous solution by solvent evaporation method. Crystal structure of metformin hydrochloride was confirmed using single crystal X–ray diffraction analysis. Work-hardening coefficient and Newtonian resistance pressure of the crystal has been estimated using Vickers hardness measurement. Thermal analysis was performed under isothermal condition in the temperature range of 25–700°C. Coats–Redfern relation was used to evaluate the thermal data for the determination of kinetic and thermodynamic parameters. The Arrhenius equation of metformin hydrochloride is k = 0.60 x 1010 e –137473/RT mol–1s–1.