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Isolation, Phytochemical Studies and Evaluation Of Caesalpinia pulcherrima Mucilage as a Potant Superdisintegrant

Mayuri Choundikar* Prmodkumar J Shirote

The present work was carried out to study the phytochemical and physicochemical characteristics to explore the disintegration property of mucilage extracted from the seeds of Caesalpinia pulcherrima (family caesalpinaceae). Orally disintegrating tablet of Ondansetron hydrochloride dihydrate was formulated using different concentrations 2.5, 5, 7.5, 10, 12.5%w/w of isolated natural disintegrant. Ondansetron is a selective serotonin receptor antagonist used as an antiemetic in the treatment and or prophylaxis of post-operative or chemotherapy or radiotherapy induced emesis and also used in the early onset of alcoholism. The formulations were evaluated for precompression parameters such as bulk density, tapped density, compressibility index, hausner’s ratio, angle of repose. Tablets were subjected to post compressional analysis such as weight variation, hardness, friability, drug content, disintegration time, dissolution studies and it was compared with marketed formulation ONDEM MD4. The formulation having disintegrant concentration 10% w/w gives shorter disintegration in 36 sec and showed 99.81% drug release within 3 minutes. Hence the present study revealed that this natural disintegrant showed better disintegrating property and act as a natural superdisintegrant