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Formulation and Evaluation of Matrix Tablets of Albendazole for Colon Site Specific Drug Delivery

Matrix tablets of albendazole containing various proportions (20%, 25%, 30% and 35%) of guar gum, xanthum gum and dextrin were prepared by direct compression technique using 10 mm concave punch. The prepared tablets were evaluated for hardness, friability, weight variation, drug content uniformity and were subjected to in vitro drug release with and without rat caecal content (4% w / v). All formulations (F1 - F12) which shows restricted drug release in stomach and small intestine and which shows more release in colonic environment. The drug release was independent of its concentration and the mechanism of drug release followed by super case-II transport. The accelerated stability studies revealed that there was no significant change in the colour, shape and drug content. The formulation (F9) is most suitable to target colon without being released significantly in the stomach and small intestine, and also it may avoid systemic side effects in the gastrointestinal tract.