Абстрактный

Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization.

Rajnikant M Suthar, Narendra P Chotai1, Digesh D Shah, Rutvik M Thumar, Hardik K Patel, Mukesh B Jadeja

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.