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Preclinical Evaluation of Protective Effect of Cynodon dactylon Pers on Experimentally Induced Gastric Mucosal Damage

Ramesh H

The present study was undertaken to evaluate the protective effect of Cynodon dactylon pers on experimentally induced gastric mucosal damage.In this study two experimental models i.e alcohol model and indomethacin model were used. Ranitidine was taken as standard drug in both the models. Both the models consist of 4 groups with 6 rats in each group (control, standard control, test compound 300mg/kg, tests compound 450mg/kg). The control group received only ulcerogen whereas the standard control group and test compound groups were pretreated with ranitidine and Cynodon dactylon respectively before exposure to ulcerogen. 4 hours after exposure to ulcerogen the rats were sacrificed, stomachs were dissected out and opened. The total number of ulcers, size of each ulcer was noted and ulcer index was calculated. Statistical analysis was done by Mann – whitny test. A p value of < 0.05 was considered for statistical significance. In alcohol model the rats pretreated with Cynodon dactylon showed significant protection as compared to control and ranitidine pretreated groups. However in indomethacin model the rats pretreated with ranitidine has given better protection.