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Possibility of Using the Interferon Gamma Release Level As a Dynamic Biomarker

Tomonori Hirashima*, Hidekazu Suzuki, TomohiroKanai1,, Hiroko Yoshida, Yoshitaka Tamura, Norio Okamoto,Toshio Tanaka

The potential of using interferon-γ (IFN-γ) release as a biomarker was examined in the previous study. Twenty-nine patients treated with immune checkpoint inhibitors were divided into three groups according to their IFN-γ release level in the positive control after enzyme-linked immunosorbent assay. The three groups showed clear differences in clinical outcomes. IGR can be a new dynamic biomarker to determine the immunological status of a patient at the pretreatment stage or any change in the state of their immunity during the treatment of various diseases.