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Lncrna TUBA4B Inhibits Cell Migration and Invasion via Mir-127 in Non-Small Cell Lung Cancer

Xeyon Wang, Hungxi Guo*

Long non-coding RNA (lncRNA) is an important mediator involved in cancer progression. Previous studies have confirmed that TUBA4B is low expressed in tumor diseases. The potential impact of TUBA4B on the progression of non-small cell lung cancer remains unknown. In this article, TUBA4B was found to be down-regulated in non-small cell lung cancer tissues, and its levels are related to the stage of non-small cell lung cancer, tumor size, and lymph node metastasis. Further experiments showed that overexpression of TUBA4B in A549 cells inhibited the invasion and migration of non-small cell lung cancer cells. TUBA4B regulates the expression of miR127, and the expression of TUBA4B is negatively correlated with miR-127 in non-small cell lung cancer tissues. Rescue tests confirmed that TUBA4B regulates cell invasion and migration through miR-127 in non-small cell lung cancer. Overall, our results suggest that the TUBA4B/miR-127 axis affects the progression of non-small cell lung cancer and provides a potential new target for patients with non-small cell lung cancer.