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Lidocain Effect on Inflammation seen from sICAM-1 in Patients with Coronary Artery Bypass Graft Surgery

Reza Widianto Sudjud, Cindy Elfira Boom, Sri Endah Rahayuningsih and Tatang Bisri

About 9.3 percentage over 1000 per year coronary artery disease in Asia- Pacific needs coronary artery bypass grafting. Coronary artery bypass grafting is an aggressive surgery that may lead to damage of vascular endothelia. Inflammatory response on coronary artery bypass grafting are induced by ischemic condition during aortic cross-clamping which is followed by reperfusion, causing oxidative stress that increase production of reactive oxygen species (ROS) which can stimulate formation of intercellular adhesion molecule-1 (ICAM-1). This study aims to analyze whether administration of intravenous lidocaine in coronary artery bypass grafting utilizing cardiopulmonary bypass machine may inhibit formation of sICAM-1. This randomized double blind controlled experimental study with permutation block randomization involves 30 patients who were underwent coronary artery bypass grafting. Patients were divided into two groups, 15 patients on lidocaine group and 15 patients on placebo group. Blood tests of sICAM-1 level were performed during preinduction, 8 and 12 h post utilization of cardiopulmonary bypass machine. Data was analyzed using unpaired T-test and Chi-squared method, with p value <0.05 assuming a significant result. Statistical analysis showed sICAM-1 level in lidocaine group on 8 and 12 h post utilization of cardiopulmonary bypass machine was lower than placebo group with significant difference (p<0.05). Conclusion: Administration of intravenous lidocaine in coronary artery bypass grafting utilizing cardiopulmonary bypass machine may inhibit formation of sICAM-1.