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Biosynthesis of Glucaric Acid with Microbial Cell Factories

Zhen Kang and Xu Gong

Glucaric acid is a kind of organic acid and widely used in food, medicine and chemical industries. During the past decade, model microorganisms such as Escherichia coli and Saccharomyces cerevisiae have been engineered for production of glucaric acid. Especially, Pichia pastoris has also been engineered for production of glucaric acid with the highest reported value. In this commentary, recent efforts and advances for glucaric acid biosynthesis were discussed