Абстрактный

Activating Organ’s Immunizing Power Against COVID–19– Learning from SARS

Yi Wang

Background: Coronaviruses cause respiratory diseases in many animals, including humans. The disease such as SARS has a fatality rate of 15 percent in patients before the age of 60 and more than 40 percent in older patients. The spike–ACE2 complex mediates their entry to host cell and independent from drug therapy inhabit the formation of such kind of complex and people can have complicated immunocompetence to against virus. 

Result: Spike protein is an important component of coronavirus structure. Molecular docking experiment revealing the potential capacity for C–type lectin to interact with spike protein obstructs the formation of spike–ACE2 complex. Based on the expression profile of C–type lectin family during infection, we predicting certain member of this kind of protein as potential therapeutic target such as Clec7a, Clec12a and Clec11a, corresponding immune cell types such as CD4/CD28 T–cell, antigen adjuvant with similar C–type lectin receptor–TDM and some immune–boosting drugs–radix sophorae, lactoferrin and Astragalus membranaceus for future testing. 

Conclusion: C-type lectin-dependent immune cell regulation network may be the potential therapeutic targets for the disease caused by Coronaviruses infecting.