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A perspective on Systemic lupus erythematosus (SLE)

Puja, Ankita, Mamatha M

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune disorder. It affect multiple organs like skin, joints, kidneys, brain, and other organs. Although liver dysfunction is not considered the main organ pathology or prognostic factor in patients with Systemic Lupus Erythematosus (SLE), it is not uncommon during the course of SLE. Liver complications in patients with SLE may be caused by lupus hepatitis (SLE-related hepatitis); autoimmune liver diseases, such as Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC); viral hepatitis; and drug-induced liver injury. Here, liver complications in patients with SLE are reviewed with a predilection for females, with a female-to male ratio of between 4.3 and 13.6, and a mean age at diagnosis of 34.3 years. Most are young women of childbearing age who suffer from such symptoms as intense fatigue and exhaustion, joint pains, thinking and memory problems, and skin rashes. In young adult women the peak incidence of about 5 in 100 000 per year.