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Wound healing activity of BrugmansiasuavelensBercht. &Presl. leaves methanol extract on Wistar albino rats

Sanjay Mavanuri, Varsha Patil, Manjunatha Hanumanthappa, ShivarudrappaB.Bhairappanavar Sadashiv. S. ., SanthoshKondajji Hanumanthappa, Venkatarangaiah Krishna, Chandrashekhar Unakal

The methanolic leaf extract of BrugmansiasuaveolensBercht. &Presl.was subjected for scientific investigation to support its traditional use as wound healer. Wound healing activity was evaluated in different concentrations prepared as an ointment in sodium alginate using five groups of six Wistaralbino male rats in each model with povidone iodine (5%) as the standard drug. Wound healing was assessed by a rate of wound contraction, tensile strength and histological changes. The results demonstrate high rate of wound contraction, higher wound breaking strength in experimental animals treated with 50 mg kg-1 of methanolic extract as compared to control and standard povidone iodine. These findings were further confirmed by histological examination of granulation tissue with a lesser number of chronic inflammatory cells, decreased edema and increased collagenation than the corresponding controls. However, effectiveness of plant extract’s wound healing property needs to be further verified before being considered for clinical purpose.