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UV-Spetrophotometric Method Development and Validation for Determination of Linezolid in Pharmaceutical Dosage Form.

Nagaraju PT, Sreenivasa Rao M, Ravi Kumar C, Mabhasha D, K Venu Gopal, and Murali Krishna NV

A simple, precise and economical second order derivative method has been developed for the estimation of Linezolid in bulk and pharmaceutical formulations. In this method Linezolid showed sharp peak at 252 nm when n= 1 and linearity was measured at 252 nm. It obeyed Beer’s law in the concentration range of 1-6 mcg/ml. The LOD and LOQ were found to be 0.36 mcg/ml and 1.11 mcg/ml respectively. A recovery of Linezolid in tablet formulation was observed in the range of 98.30-101.09%. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Linezolid in bulk and pharmaceutical formulations.