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Synthesis and characterization of chemically modified collagen based nanobiocomposite containing silver nanorods incorporated with ciprofloxacin

S. Sekar, R. Manikandan, A. Mandal, S. Sankar, T.P. Sastry

Recently development of nanobiocomposites (NBC) from biowastes, which has potential biomedical applications has gained momentum. Extraction of collagen for biomedical applications from biowastes such as fish scales has received much attention. The present study aims at designing a biocompatible collagen based NBC impregnated with silver nanorods (AgNRs) and coupled with ciprofloxacin to make it suitable for biomedical purposes. Collagen coated AgNRs were graft co-polymerized with a biocompatible polymer, glycidyl methacrylate (GMA), and coupled with an antibiotic, ciprofloxacin (C-Ag-G-D). Infrared spectroscopy studies confirmed the grafting of GMA on C while SEM images showed coating of collagen on silver nanorods. DSC and TGA results indicate higher denaturation temperature with improved thermal stability for the NBC. Antimicrobial studies using E.Coli have shown enhanced antibacterial effect for the NBC. Thus, C-Ag-G-D nanobiocomposite with improved thermal stability and antibacterial activity might be a suitable candidate for biomedical applications.