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Synthesis and Antimicrobial Evaluation of Novel Substituted Acetamido- 4-subtituted-thiazole-5-indazole Derivatives

Pawar CD and Shinde DB

A series of novel molecules containing thiazole and indazole ring structure were designed and synthesized. The compounds are synthesized on gram scale by using series of reactions having vicarious reaction and coupling reactions. We have optimized all the reaction steps for getting good yields. For first time we have synthesized substituted indazole acetic acid which is coupled with different substituted thiazoles. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR Mass spectrum and the purity was checked through HPLC analysis. Compounds 4a-4j are tested for antimicrobial activity, and results shows most of compounds showing promising antimicrobial activity.