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Synthesis and Anti-inflammatory Evaluation of 1,2,4 Triazole Derivatives

Meenakshi Virmani, Sabir Hussain

A mixture of 4-hydroxyphenylacetic acid, absolute ethanol, few drops of concentrated sulphuric acid along with a small porcelain chip on reaction formed Ethyl-(4-hydroxyphenyl) acetate (1). On condensing mixture of (1), hydrazine hydrate and absolute ethanol formed 4-Hydroxyphenyl acetic acid hydrazide (2). Further mixture of 2, aryl/alkyl isothiocyanate and ethanol was refluxed and formed N1-[2-(4-Hydroxyphenyl) acetyl] N4-alkyl/aryl-3-thiosemicarbazide (3a-i). A suspension of (3a-3i) in ethanol, sodium hydroxide is refluxed for 2 hours on a water bath and formed 5-(Hydroxyphenyl) methyl-4-alkyl/aryl-2-mercpto-1,2,4(H)-triazoles (4a-i). The 1,2,4-triazole derivatives of 4-hydroxyphenyl acetic acid (4a-i) showed anti-inflammatory activity and Ibuprofen was taken as the standard drug