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Subclinical Hypothyroidism and Anti-Thyroperoxidase Antibodies

Vidyasree S, Prasad SYG, Niranjankumar M, Rahmatulla S, Ranakishor P*, Srinivasababu R

Subclinical hypothyroidism (SCH) refers to the serum thyrotropin (or TSH) concentration above the reference range with normal serum free levothyroxine (fT4). The leading cause for raised thyrotropin concentration in SCH is not due to iodine deficiency but rather due to excessive intake of iodine that results in the development of anti-TPO antibodies towards thyroid peroxidase enzyme. Most common symptoms reported are muscle cramps, slowness of thinking, throat harshness and constipation. Most of the clinicians believe that those individuals having thyrotrophic concentration greater than 10 mIU/L should undergo the treatment of levothyroxine (LT4). The results of many epidemiological studies states that, greater the concentration of Anti-Thyroperoxidase antibodies then greater the susceptibility of having overt hypothyroidism in SCH individuals.