Абстрактный

Review on Lyophilization of Anti-biotics

Anupama P

The process of Lyophilization is carried out in pharmaceutical solutions inorder to produce an acceptable and stable product has been a practice employed to manufacture many marketed injectable formulations. Lyophilization which is based on the principle of sublimation of ice is a process of removal of water by, conversion of ice directly from solid to vapour without passing through a liquid phase. It includes the processes like freezing, sublimation and desorption. The present marketed formulation is taking more amount of time to get lyophilized and is facing problem of cake integrity during transport and upon prolonged storage. So the present work is designed to formulate a lyophilized Piperacillin tazobactam powder for injection, with decreased lyophilization time, increased stability and make the product more economical. Thus, the important objective of this research is to formulate a stable lyophilized formulation with desired characteristics, by combining with different excipients