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Re-Evaluating Antidiabetic Effect of Pioglitazone in Alloxan Induced Diabetic Animal Model

Saurabh Srivastava, Shalini Gupta, Devendra Kumar, and Rakesh Kumar Dixit

The study includes the pharmacological screening on Pioglitazone, which is an effective and frequently prescribed treatment for type 2 diabetes. An in-vivo study included three animal models with six mice in each, one was control or untreated and other two groups were alloxan and one group drug treated to compare the pharmacological response of pioglitazone against diabetic. Alloxan was used to induce diabetes in animals. Alloxan, a β-cytotoxin, chemically called mesoxalylurea, mesoxalylcarbamide, and 2, 4, 5, 6-tetra-oxohexahye-4-pyrimide or pyrimidine tetrone has been extensively used for in vivo induction of „chemical diabetes‟ in animals. Administration of Pioglitazone reduced serum glucose level in alloxan (70 mg/kg) induced diabetic mice as compared to vehicle.