Rana Kausar, Nazish Waris
The excess of uric acid in blood results in hyperuricemia which can also lead to other conditions, like kidney stones (uric acid nephrolithiasis) and kidney failure etc. Excess of uric acid is removed from the body by using different drugs which also produces harmful effects on other organs in many cases. But, in the current study, treatment was done by bottle gourd which not only helped to remove excess uric acid in blood, but also other organs remained unaffected. In the current study, uric acid was increased by direct oral dose of uric acid. Rats were divided into four groups: control, zyloric treated, bottle gourd orally treated and bottle gourd extract treated. After three weeks of treatment behavioural activity was monitored by locomotors activity in open field experiment, stimulatory activity in home cage, anxiolytic effects in light and dark apparatus and also in T maze, antidepressants by forced swimming activity, short term memory (STM) and long term memory (LTM) by water maize activity, were significantly increased in bottle gourd orally treated rats. After decapitation, laboratorial activity was determined by LFT (liver function test) including, ALT, GGT, creatinine and BUN to analyse liver and kidney effect. Results of bottle gourd orally treated rats showed a good effect on LFT as compare to extract and Zyloric treated rats. Behavioural and laboratorial variables were analysed by using SPSS v. 20 and p-value <0.05 was considered statistically significant. Thus, the aim of the study is to enhance the function of bottle gourd as an ant uric acid agent.
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