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Intestinal Absorption Models

Karthik Maddula, Anusha Juluru

The intestinal epithelium is the barrier which regulates the entry of xenobiotics and nutrients. Understanding of the absorption and metabolism of those materials at the intestinal mucosal level is very important because it regulates the bioavailability of those substances. Any xenobiotic entering the systemic circulation has to pass through the epithelial layer, section of the lamina propria, and the wall of the respective vessel. It is important to select suitable model for understanding the rate limiting step in the absorption process.