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In Vitro Free Radical Scavenging and Membrane Stabilizing Activity of Paederia foetida Leaves

Riaz Uddin, Raushanara Akter, SM Raquibu Hasan, Ehsanu Hoque Mazumder, and Md Ashraful Alam

Paederia foetida is a native Bangladeshi plant, used for the treatments of various diseases in folklore medicine. In this study, the antioxidant potential of Paederia foetida extract was evaluated by using a series of well established antioxidant assay systems. Paederia foetida extract scavenge DPPH radical in a dose dependent manner. The extract was also showed potent free radicals inhibitory activity generated from sodium nitroprusside as nitric oxide and free radicals from H2O2. Furthermore, Paederia foetida extract showed moderate reducing power and potent membrane stabilizing activity of RBC membrane in hypotonic medium. The extracts exhibited remarkable antioxidant activities in all system studied. Scavenging of reactive oxygen species (ROS) may be attributed to the high amount of phenolic compounds present in the extract. Further study is necessary for isolation and characterization of the antioxidants present in the extract, which may serve as a potential source of natural healer for oxidative stress and inflammatory diseases.