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Hypovitaminosis D:Association With Altered Blood Lipid Profile

Reshma K, AlapChristy, Sudha K

Although India is a country full of sunshine, it is reported that 80% of healthy Indians are deprived of the sunshine vitamin ,vitamin D. Some of the risk factors for the same include non white ethnicity, obesity, less outdoor activity and age. Vitamin D status has been correlated with PTH status, blood pressure, Type I & II diabetes mellitus in humans .Reports on studies linking vitamin D with dyslipidemia amongst Indians is scarce. Since vitamin receptor and 1α hydroxylase gene is reported to be present in human adipocytes, white adipose tissue may be a direct target of Vitamin D. The present study aims at establishing a correlation between vitamin D status and lipid profile in the coastal belt of South India where dyslipidemia is prevalent.A total of 76 subjects in the age group 20-50 years were included in the study and categorized under 2 groups-Group1(n=62) had suboptimal levels of vitamin D(<29 ng/ml)and group 2(n=14) had optimal levels of vitamin D(>29 ng/ml).Lipid profile was analysed in both groups. Group 1 had higher levels of cholesterol (p=0.05) and triglyceride levels (p=0.049) as compared to Group 2 although mean values in both groups were in the normal range.Accordingly, this group showed significantly higher levels of VLDL and LDL. Pearson correlation studies of vitamin D with lipid profile in both genders showed a negative correlation in all parameters while significant correlation was observed in males with respect to total cholesterol,LDL and total cholesterol to HDL ratio. In females vitaminD deficiency influenced only serum cholesterol levels significantly.Based on these findings, it is imperative to state that suboptimal levels of vitamin D may be implicated in the development of dyslipidemia,especially in male population