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Fabrication of gelatin based composites containing bimetallic Ag-Au nanoparticles for biomedical applications

A. Mandal, T.P. Sastry

Recently, focus is directed on research which involves synthesis of nanoparticles using natural polymericmaterials that are eco friendly, inexpensive as well as biodegradable. In this study, bimetallic silver-gold nanoparticles (Ag-AuNPs) were synthesized usinggelatinextracted from chrome containing leather waste as a template.The nanoparticles were confirmed with UV-Vis and particle size analysis. The gelatin directed bimetallic nanoparticles were air driedto obtain as nanobiocomposites (NBCs). These NBCs were characterized via FTIR, DSC, TGA, XRDand SEM/EDX. Also, mechanical properties such as tensile strength and Young’s modulus along with water absorption studies of the NBCs were conducted.The results indicate that the gelatin NBCs incorporated with bimetallicnanoparticles are biodegradable and possess the desired mechanical propertiesneededfor biomedical applications. Moreover, the in vitro results demonstrate the viability of fibroblast (NIH 3T3) cells with gelatin based NBCs.The gelatin NBCincorporated with Ag-Au NPs isbiocompatible and can be used as scaffolds which have potential for various biomedical applications.