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Early Evaluation of Etilological Treatmetn in Young Adults, Chronically Infected Trypanosama Cruzi Detected Using Polymerase Chain Reaction

K.Sathish, Dr.S.Niraimathi, S.Justin Jayaraj, K.Kamalakannan

Fourteen patients (age limits: 18-30) chronically infected with Trypanosoma cruzi and presenting positive blood PCR reactions, were submitted to etiological treatment with benznidazole, in Nagapattinam district rural an area. A control group of five patients of the same age and positive by PCR did not receive treatment. Post-treatment follow-up was performed with PCR and conventional serology. PCR became negative in 12/14 of the treated patients after six months follow up, compared to 1/5 in the control group (p = 0.01). All patients remained serologically positive after treatment. The reduction of PCR signals of infection after treatment may become an early evidence of cure in chronically infected young adult patients.