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Development and Validation of RP-HPLC Method: An Overview.

M Sangeetha, C Rubina Reichal, VN Indulatha, and N Thirumoorthy

The present study focuses on the various steps, parameters involved in HPLC condition. Various applications of this system also discussed. HPLC process development is important in case of drug discovery, drug development and pharmaceutical products. It can be adopted apparently for routine quality control study of research and formulation tests. This article mainly focuses on the optimization of HPLC conditions and other important aspects during method of process development and validation of drug substances. The steps involved in the method development and analytical validation was discussed, an advantage over the method was explained elaborately.