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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TICAGRELOR: REVIEW

MEENA IYER*, SOWMYA H G, JOSE GNANA BABU C

Analytical method development and validation play important roles in the discovery and Manufacture of pharmaceuticals. Method development is the process of proving that an analytical method is acceptable for use to measure the concentration of a Ticagrelor in a compounded dosage form. The analytical method validation is essential for analytical method development and tested extensively for specificity, linearity, accuracy, precision, range, detection limit, and robustness. Literature survey reveals that the analytical methods based on UV spectroscopy, UPLC and RP-HPLC for the determination of Ticagrelor individually and in combination with other drugs. The methods were validated according to ICH guidelines. The developed methods are simple, sensitive, and reproducible and can be used for the routine analysis of Ticagrelor in bulk and Tablet dosage form.