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A Review of Hot Melt Extrusion Technique

Ankit Patel, Deepak Sahu, Ashok Dashora, Rahul Garg, Piyush Agraval, Pratik Patel6, Parth Patel, Gaurang Patel

Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems.HME is a solvent free process that achieves solid molecular dispersions by a melt blending process, in which the API is dispersed and or dissolved into a polymeric matrix. HME is an excellent alternative to other conventionally available techniques such as roll spinning and spray drying. In This paper we review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.